Scientific Publications
Treatment of the Heart Failure Patient with Atrial Fibrillation: A Major Unmet Need
JACC: Heart Failure, 2013
Adrenergic Receptor Polymorphisms and Prevention of Ventricular Arrhythmias with Bucindolol in Patients with Chronic Heart Failure
Circulation: Arrhythmia and Electrophysiology, 2013
Effect of Bucindolol on HF Outcomes and Heart Rate Response in Patients with Reduced Ejection Fraction HF and Atrial Fibrillation
European Journal of Heart Failure, 2012
Combinatorial Pharmacogenetic Interactions of Bucindolol and Beta-1, Alpha-2C Adrenergic Receptor Polymorphisms
PLOS ONE, 2012
The Development of Beta-Adrenergic Receptor Antagonists for the Treatment of Heart Failure: A Paradigm for Translational Science
Circulation Research, 2011
Treatment of Chronic Heart Failure with Beta-Adrenergic Receptor Antagonists: A Convergence of Receptor Pharmacology and Clinical Cardiology
Circulation Research, 2011
An α2c – Adrenergic Receptor Polymorphism Alters the Norepinephrine-Lowering Effects and Therapeutic Response of the β-Blocker Bucindolol in Chronic Heart Failure
Circulation: Heart Failure, 2010
Quality of Life and Prognosis in Heart Failure: Results of the Beta-Blocker Evaluation of Survival Trial (BEST)
Journal of Cardiac Failure, 2007
A Polymorphism Within a Conserved β1-adrenergic Receptor Motif Alters Cardiac Function and β-blocker Response in Human Heart Failure
The National Academy of Sciences, 2006
Impact of Nonfatal Myocardial Infarction on Outcomes in Patients With Advanced Heart Failure and the Effect of Bucindolol Therapy
The American Journal of Cardiology, 2005
Effect of Baseline or Changes in Adrenergic Activity on Clinical Outcomes in the Beta-Blocker Evaluation of Survival Trial (BEST)
Circulation, 2004
β1 – Adrenergic Receptor Polymorphisms Confer Differential Function and Predisposition to Heart Failure
Nature Medicine, 2003
A Comparative Analysis of the Results from 4 Trials of β-Blocker Therapy for Heart Failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS
Journal of Cardiac Failure, 2003
The Effect of Diabetes on Outcomes of Patients With Advanced Heart Failure in the BEST Trial
Journal of the American College of Cardiology, 2003
Synergistic Polymorphisms of β1 and α2c – Adrenergic Receptors and the Risk of Congestive Heart Failure
New England Journal of Medicine, 2002
A Trial of the Beta-Blocker Bucindolol in Patients with Advanced Chronic Heart Failure
New England Journal of Medicine, 2001
Dose Response of Beta-Blockers in Adrenergic Receptor Polymorphism Genotypes
Circulation: Genomics and Precision Medicine, a Journal of the American Heart Association
Pharmacogenetic Guided Beta-blocker Therapy with Bucindolol for the Prevention of Atrial Fibrillation/flutter in Heart Failure: Relationship of Left Ventricular Ejection Fraction to Treatment Effect
HFSA 2019 Scientific Meeting
Pharmacogenomic Guided Beta-Blocker Therapy with Bucindolol Reduces Atrial Fibrillation Burden Compared to Metoprolol Succinate: The GENETIC-AF Trial
Heart Rhythm Society 2020 Scientific Sessions
Impact of Pharmacogenetic-guided Bucindolol versus Metoprolol Succinate on the Overall Burden of Clinical Events in Patients with AF and Heart Failure: The GENETIC-AF Trial
Heart Rhythm Society 2020 Scientific Sessions
Bucindolol is Associated with a Lower Incidence of Dose Limiting Bradycardia in Heart Failure Patients with Atrial Fibrillation: The GENETIC-AF Trial
Heart Rhythm Society 2020 Scientific Sessions